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MIDDLE SCHOOL KIT:
Activity 3


Viruses vs. Bacteria.
Viruses are very different from bacteria. For one thing, they are much smaller. Viruses cannot be seen through an ordinary microscope. For another, we are not sure they are really alive. They act like robots that can turn on and turn off. For more on the differences between viruses and bacteria, go to Bugs! on the Save the Antibiotic Website.

Here are images of six viruses that cause disease in humans:

  • Adenovirus (click here for the image). The Human Adenoviruses most commonly cause respiratory illnesses like colks, pneumonia, croup and bronchitis. Some adenoviruses can cause infections of the bowel or bladder.
  • Coxsackie B virus (click here for the image). Coxsackie B virus diseases can range from relatively minor gastrointestinal upsets to paralysis, cardiac damage, and birth defects,.
  • Hepatitis A virus (click here for the image). Hepatitis A is a viral infection of the liver caused by hepatitis A virus. The illness may be mild, lasting a week or two, or severely disabling.
  • Norwalk virus (click here for the image). The Norwalk virus is a leading cause of foodborne disease in the United States. The symptoms include nausea, diarrhea, vomiting and stomach cramps.
  • Poliovirus (click here for image). Polio is an infectious disease caused by a the Human Poliovirus. It can strike at any age, but affects mainly children under three (over 50% of all cases). The disease causes paralysis, which is almost always permanent. Fortunately, this dread disease has almost been wiped out all across the globe. Check out the Polio Eradication Website.
  • Rhinovirus (click here for image). Billions of people catch colds every year. Two thirds of them are caused by the Rhinovirus.

The following five images are of bacteria that cause human illnessses:

  • Campylobacter jejuni (click here for the image). Most people who become ill with campylobacteriosis get diarrhea, cramping, abdominal pain, and fever.
  • Cholera (click here for the image). A person may get cholera by drinking water or eating food contaminated with the cholera bacterium. In an epidemic, the source of the contamination is usually the feces of an infected person.
  • Salmonella (click here for the image). Salmonellosis is a common form of food poisoning. Most persons infected with Salmonella develop diarrhea, fever, and abdominal cramps.
  • Shigella (click here for the image). Most who are infected with Shigella develop diarrhea, fever, and stomach cramps starting a day or two after they are exposed to the bacterium. Most Shigella infections are the result of the bacterium passing from stools or soiled fingers of one person to the mouth of another person.
  • Streptococcus pyogenes (click here for the image). Streptococcus pyogenes is one of the most frequent pathogens found in humans. These bacteria are the causes of pharyngitis (Strep Throat), scarlet fever, impetigo and the rare but severe invasive infections described in the news media as "flesh-eating bacteria." There's more information on the University of Wisconsin – Madison Website.

Mechanism of infection: Bacteria.
When bacteria infect the body they reproduce quickly, forming colonies that feed on nutrients in the host cells. The mechanism of infection may be different for different kinds of bacteria. Enteropathogenic E. coli attach to the wall of an intestinal cell and build a platform from which to begin reproduction.

Enteropathogenic E. coli Infection Mechanism

To view the animations, click here.

source: Howard Hughes Medical Institute (www.hhmi.org/biointeractive.index.html)

Mechanism of infection: Viruses.
Viruses cannot reproduce by themselves. Instead, they infect cells by injecting DNA through the cell wall. The viral DNA takes control of the cell and turns it into a factory for producing more viruses.


Click here
to view animation

How a Virus
Infects a Cell


Click here
to view animation

Bacteriophage (virus)
Infects a Bacterial Cell

How antibiotics affect viruses.
Penicillin kills bacteria by interfering with the bacterial cell's ability to build new cell wall. When the cell expands, getting ready to divide, the cell wall stretches and breaks.


Click here
to enlarge image

Note that growth of the bacteria Staphylococcus aureus is inhibited in the area surrounding the invading penicillin-secreting Penicillium mold colony.

Slide by Christine L. Case, Ed.D
Professor of Microbiology
Skyline College, California

Reducing the spread of infectious diseases
Washing your hands regularly may be the single best way to stay well yourself, and prevent the spread of infectious diseases. There are more simple things you can do at home and at school to fight infection. To learn about them, visit the Bugbusters section of the Save the Antibiotic Website.